In 1984, Dr. Barry Marshall had a theory about ulcers that he couldn't convince the science community of. So, he took matters into his own hands... or stomach, and infected himself with a potentially deadly bacterium.

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Sources:
https://medlineplus.gov/pepticulcer.html
http://discovermagazine.com/2010/mar/07-dr-drank-broth-gave-ulcer-solved-medical-mystery
https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/h-pylori-fact-sheet#q4
https://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/warren-slides.pdf
https://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/warren-lecture.pdf
https://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/marshall-lecture.pdf
https://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/press.html
https://www.cdc.gov/ulcer/history.htm
https://www.ncbi.nlm.nih.gov/books/NBK2432/
https://www.nobelprize.org/nobel_prizes/medicine/laureates/2005/
Martin Blaser's "Missing Microbes" book, pp. 104-152
http://www.newyorker.com/magazine/2012/10/22/germs-are-us
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283743/
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(84)91816-6/abstract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539101/